Extramammary Paget's Disease: 20 years of Experience in Chinese Population

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The dynamics of apparent horizons in Robinson-Trautman spacetimes

We present an alternative scheme of finding apparent horizons based on spectral methods applied to Robinson-Trautman spacetimes. We have considered distinct initial data such as representing the spheroids of matter and the head-on collision of two non-rotating black holes. The evolution of the apparent horizon is presented. We have obtained in some cases a mass gap between the final Bondi and apparent horizon masses, whose implications were briefly commented in the light of the thermodynamics of black holes.Comment: 9 pages, 7 figure

Awareness Versus Un-Clinging: Which Matters in Mindfulness?

Awareness and un-clinging have been emphasised in Buddhist discourse as important facets of mindfulness practice for over 2500 years. However, there is a lack of rigorous research examining the relationship between these two elements and their importance to well-being. To evaluate these abstract constructs, the current study adopted multiple assessment modalities; namely, a self-report scale, experience sampling (assessing ‘momentary mindfulness’), and semi-structured interviews (assessing ‘rater-rated mindfulness’). A total of 415 participants completed the questionnaire survey. Among them, 71 participants further took part in the experience sampling procedure and semi-structured interviews. The findings reveal that self-reported awareness was mildly correlated with momentary mindfulness (r = .35) but was not significantly correlated with rater-rated mindfulness. Self-reported un-clinging was moderately correlated with rater-rated mindfulness (r = .53) but was not significantly correlated with momentary mindfulness. Un-clinging, but not awareness, can distinguish meditators from non-meditators. Lastly, based on the Buddha’s mindfulness discourse, a path analysis model illustrates that the effects of un-clinging and awareness on stress reduction are mediated by emotional intelligence and non-attachment. Practical implications and future research designs are discussed

Fine-grained bit-flip protection for relaxation methods

[EN] Resilience is considered a challenging under-addressed issue that the high performance computing community (HPC) will have to face in order to produce reliable Exascale systems by the beginning of the next decade. As part of a push toward a resilient HPC ecosystem, in this paper we propose an error-resilient iterative solver for sparse linear systems based on stationary component-wise relaxation methods. Starting from a plain implementation of the Jacobi iteration, our approach introduces a low-cost component-wise technique that detects bit-flips, rejecting some component updates, and turning the initial synchronized solver into an asynchronous iteration. Our experimental study with sparse incomplete factorizations from a collection of real-world applications, and a practical GPU implementation, exposes the convergence delay incurred by the fault-tolerant implementation and its practical performance.This material is based upon work supported in part by the U.S. Department of Energy (Award Number DE-SC-0010042) and NVIDIA. E. S. Quintana-Orti was supported by project CICYT TIN2014-53495-R of MINECO and FEDER.Anzt, H.; Dongarra, J.; Quintana Ortí, ES. (2019). Fine-grained bit-flip protection for relaxation methods. Journal of Computational Science. 36:1-11. https://doi.org/10.1016/j.jocs.2016.11.013S11136Chow, E., & Patel, A. (2015). Fine-Grained Parallel Incomplete LU Factorization. SIAM Journal on Scientific Computing, 37(2), C169-C193. doi:10.1137/140968896Karpuzcu, U. R., Kim, N. S., & Torrellas, J. (2013). Coping with Parametric Variation at Near-Threshold Voltages. IEEE Micro, 33(4), 6-14. doi:10.1109/mm.2013.71Bronevetsky, G., & de Supinski, B. (2008). Soft error vulnerability of iterative linear algebra methods. Proceedings of the 22nd annual international conference on Supercomputing - ICS ’08. doi:10.1145/1375527.1375552Sao, P., & Vuduc, R. (2013). Self-stabilizing iterative solvers. Proceedings of the Workshop on Latest Advances in Scalable Algorithms for Large-Scale Systems - ScalA ’13. doi:10.1145/2530268.2530272Calhoun, J., Snir, M., Olson, L., & Garzaran, M. (2015). Understanding the Propagation of Error Due to a Silent Data Corruption in a Sparse Matrix Vector Multiply. 2015 IEEE International Conference on Cluster Computing. doi:10.1109/cluster.2015.101Chazan, D., & Miranker, W. (1969). Chaotic relaxation. Linear Algebra and its Applications, 2(2), 199-222. doi:10.1016/0024-3795(69)90028-7Frommer, A., & Szyld, D. B. (2000). On asynchronous iterations. Journal of Computational and Applied Mathematics, 123(1-2), 201-216. doi:10.1016/s0377-0427(00)00409-xDuff, I. S., & Meurant, G. A. (1989). The effect of ordering on preconditioned conjugate gradients. BIT, 29(4), 635-657. doi:10.1007/bf01932738Aliaga, J. I., Barreda, M., Dolz, M. F., Martín, A. F., Mayo, R., & Quintana-Ortí, E. S. (2014). Assessing the impact of the CPU power-saving modes on the task-parallel solution of sparse linear systems. Cluster Computing, 17(4), 1335-1348. doi:10.1007/s10586-014-0402-

Three little pieces for computer and relativity

Numerical relativity has made big strides over the last decade. A number of problems that have plagued the field for years have now been mostly solved. This progress has transformed numerical relativity into a powerful tool to explore fundamental problems in physics and astrophysics, and I present here three representative examples. These "three little pieces" reflect a personal choice and describe work that I am particularly familiar with. However, many more examples could be made.Comment: 42 pages, 11 figures. Plenary talk at "Relativity and Gravitation: 100 Years after Einstein in Prague", June 25 - 29, 2012, Prague, Czech Republic. To appear in the Proceedings (Edition Open Access). Collects results appeared in journal articles [72,73, 122-124

Academic Performance and Behavioral Patterns

Identifying the factors that influence academic performance is an essential part of educational research. Previous studies have documented the importance of personality traits, class attendance, and social network structure. Because most of these analyses were based on a single behavioral aspect and/or small sample sizes, there is currently no quantification of the interplay of these factors. Here, we study the academic performance among a cohort of 538 undergraduate students forming a single, densely connected social network. Our work is based on data collected using smartphones, which the students used as their primary phones for two years. The availability of multi-channel data from a single population allows us to directly compare the explanatory power of individual and social characteristics. We find that the most informative indicators of performance are based on social ties and that network indicators result in better model performance than individual characteristics (including both personality and class attendance). We confirm earlier findings that class attendance is the most important predictor among individual characteristics. Finally, our results suggest the presence of strong homophily and/or peer effects among university students

Eosinophilic Enteritis Confined to an Ileostomy Site

Eosinophilic enteritis is a rather rare condition that can manifest anywhere from esophagus to rectum. Its description in the literature is sparse, but associations have been made with collagen vascular disease, malignancy, food allergy, parasitic or viral infections, inflammatory bowel disease, and drug sensitivity. We present the case of a 41-year-old male diagnosed with ulcerative colitis who underwent proctocolectomy with ileal pouch anal anastomosis and loop ileostomy formation utilizing Seprafilm®, who later developed eosinophilic enteritis of the loop ileostomy site. This is the first report of eosinophilic enteritis and its possible link to the use of bioabsorbable adhesion barriers

Translational Control through eIF2alpha Phosphorylation during the Leishmania Differentiation Process

The parasitic protozoan Leishmania alternates between an invertebrate and a mammalian host. Upon their entry to mammalian macrophages, Leishmania promastigotes differentiate into amastigote forms within the harsh environment of the phagolysosomal compartment. Here, we provide evidence for the importance of translational control during the Leishmania differentiation process. We find that exposure of promastigotes to a combined elevated temperature and acidic pH stress, a key signal triggering amastigote differentiation, leads to a marked decrease in global translation initiation, which is associated with eIF2α phosphorylation. Interestingly, we show that amastigotes adapted to grow in a cell-free medium exhibit lower levels of protein synthesis in comparison to promastigotes, suggesting that amastigotes have to enter a slow growth state to adapt to the stressful conditions encountered inside macrophages. Reconversion of amastigotes back to promastigote growth results in upregulation of global translation and a decrease in eIF2α phosphorylation. In addition, we show that while general translation is reduced during amastigote differentiation, translation of amastigote-specific transcripts such as A2 is preferentially upregulated. We find that A2 developmental gene regulation is triggered by temperature changes in the environment and that occurs mainly at the level of translation. Upon elevated temperature, the A2 transcript is stabilized through its association with polyribosomes leading to high levels of translation. When temperature decreases during amastigote to promastigote differentiation, the A2 transcript is not longer associated with translating polyribosomes and is being gradually degraded. Overall, these findings contribute to our better understanding of the adaptive responses of Leishmania to stress during its development and highlight the importance of translational control in promastigote to amastigote differentiation and vice-versa